Therapeutic application of pro-apoptotic benzodiazepines
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United States of America Patent
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May 22, 2007
Grant Date -
Aug 23, 2001
app pub date -
Jan 22, 2001
filing date -
May 18, 1995
priority date (Note) -
Expired
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Abstract
Benzodiazepine compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of the following structures: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined. The invention also includes enantiomers, pharmaceutically acceptable salts, prodrugs or derivatives of the benzodiazepine compounds. Any one or more of these benzodiazepine compounds can be used to treat a variety of dysregulatory disorders related to cellular death. Such disorders include autoimmune disorders, inflammatory conditions, hyperproliferative conditions, viral infections, and atherosclerosis. In addition, the above compounds can be used to prepare medicaments to treat the above-described dysregulatory disorders. The benzodiazepines can also be used in drug screening assays and other diagnostic methods.
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