Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways
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United States of America Patent
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May 29, 2007
Grant Date -
Sep 8, 2005
app pub date -
Dec 1, 2003
filing date -
Sep 10, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. In this system, the cell is treated with a compound, and functional interaction of this compound with a cellular receptor yields a detectable signal, which can be specifically measured. The subject assays include methods of identifying compounds which specifically modulate, for example, heterologous receptors coupled to the pheromone response pathway in yeast. The subject assays are particularly amenable to the identification of specific agonists and antagonists of G protein-coupled receptors.
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