Process for the synthesis of oligomeric compounds

United States of America Patent

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Jun 5, 2007
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Jun 23, 2005
app pub date
Dec 28, 2004
filing date
Feb 4, 1999

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Abstract

Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.

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Patent Owner	Address
IONIS PHARMACEUTICALS INC	2855 GAZELLE COURT CARLSBAD CA 90210

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C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....

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Inventor Name	Address	# of filed Patents	Total Citations
Capaldi, Daniel C	Carlsbad, CA	25	390
Cole, Douglas L	Half Moon Bay, CA	192	1362
Guzaev, Andrei	Vista, CA	12	124
Krotz, Achim	San Diego, CA	11	395
Manoharan, Muthiah	Weston, MA	491	18658
Ravikumar, Vasulinga T	Carlsbad, CA	39	625

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Process for the synthesis of oligomeric compounds

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United States of America Patent

11024958

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PATENT NO	7227016
APP PUB NO	20050137390A1
SERIAL NO	11024958
DOCKET NO

US Family Size	Non-US Coverage
Patent Longevity	Forward Citations

DATE PUBLISHED	PUBLICATION/PATENT NO.	PUBLICATION TYPE
June 05, 2007	US,7227016,B2 US7227016B2	GRANTED PATENT AS SECOND PUBLICATION
June 23, 2005	US,20050137390,A1 US20050137390A1	FIRST PUBLISHED PATENT APPLICATION

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11024958

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