Polymer conjugates of proteinases
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United States of America Patent
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Jun 12, 2007
Grant Date -
Jan 16, 2003
app pub date -
Jun 28, 2002
filing date -
Jun 28, 2001
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Abstract
Methods are provided for the stabilization of proteinases by the covalent attachment of or admixture with water-soluble polymers. The resultant stabilized proteinases have increased stability under the harsh conditions used in industrial genomics, which permits their use in the extraction and isolation of nucleic acids and the identification of disease-related prion proteins at elevated temperatures in solutions containing chaotropic agents, such as sodium dodecyl sulfate, urea or guanidinium salts, conferring advantages for robotic applications.
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