Pharmaceutical formulation comprising glycine as a stabilizer

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United States of America Patent

PATENT NO 7230014
SERIAL NO

09549858

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Abstract

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The present invention provides pharmaceutical formulations suitable for intravenous injection comprising a lyophilized anti-ulcerative agent reconstituted in isotonic solutions suitable for intravenous administration, such as 5% dextrose or 0.9% sodium chloride. The solutions are brought to a pH of between about 9 and about 12, preferably between about pH 10 and 11, by a glycine-sodium hydroxide buffer. Such formulations are chemically and physically stable, and do not significantly change color, for at least between about 6 and about 12 hours at room temperature, and are stable to color change for from between about 24 and 48 hours if kept at 5.degree. C.

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Patent Owner(s)

Patent OwnerAddress
EISAL COMPANY LIMITEDBUNKYO-KU 4-6-10 KOISHIKAWA TOKYO 112-8088

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Iwamoto, Kiyoshi Kagamihara, JP 35 192
McShane, James Wake Forest, NC 13 293
Onai, Katsumi Aichi, JP 9 69
Watanabe, Sumio Aichi, JP 124 910
Wood, Ray Raleigh, NC 4 17

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