Systems and methods for preparing and analyzing low volume analyte array elements
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United States of America Patent
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Jun 19, 2007
Grant Date -
May 22, 2003
app pub date -
Jul 30, 1999
filing date -
Jan 23, 1997
priority date (Note) -
In Force
status (Latency Note)
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Abstract
Methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface. The resulting substrates are also provided. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. The tool can dispense a spot of fluid to a substrate surface by spraying the fluid from the pin, contacting the substrate surface or forming a drop that touches against the substrate surface. The tool can form an array of sample material by dispensing sample material in a series of steps, while moving the pin to different locations above the substrate surface to form the sample array. The prepared sample arrays are passed to a plate assembly that disposes the sample arrays for analysis by mass spectrometry. To this end, a mass spectrometer is provided that generates a set of spectra signals that are indicative of the composition of the sample material under analysis.
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