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Abstract

Quinazoline derivatives have the formula: ##STR00001## or the pharmaceutically acceptable salts thereof; wherein each of Z.sup.5, Z.sup.6, Z.sup.7 and Z.sup.8 is N or CH and wherein one or two Z.sup.5, Z.sup.6, Z.sup.7 and Z.sup.8 are N and wherein two adjacent Z positions cannot be N; wherein m and n are each independently 0 3; wherein R.sup.1 is independently OH, SH, NH.sub.2, OR, SR, NHR, halo or R-halide; wherein two adjacent R.sup.1 groups may be joined to form an aliphatic hetero cycle ring of 5 6 members; wherein R.sup.2 is independently R, halo, R-halide, OR-halide, NH.sub.2, CONH.sub.2 or CONHR; wherein R is optionally substituted C.sub.1 C.sub.12 alkyl, C.sub.1 C.sub.12 alkenyl, C.sub.1 C.sub.12 alkynyl, or aryl C.sub.1 C.sub.12 alkyl, containing 0 4 heteroatoms in place of a carbon in the carbon backbone, where the optional substituents are .dbd.O, .dbd.N, or OH; and wherein R.sup.3 is H or CH.sub.3. Such compounds are useful in pharmaceutical compositions and methods of treating conditions characterized by enhanced TGF.beta. activity.

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First Claim