Nucleic acid sequences encoding Conus protein disulfide isomerase
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United States of America Patent
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Jul 3, 2007
Grant Date -
Sep 7, 2006
app pub date -
Aug 31, 2005
filing date -
Feb 28, 2003
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Abstract
Protein disulfide isomerase is a major component of Conus venom ducts. The invention relates to a protein disulfide isomerase (PDI) from Conus snails, a nucleic acid sequence encoding the Conus protein disulfide isomerase, and to methods for folding disulfide-rich peptides using a protein disulfide isomerase. Oxidative folding of conotoxin precursors, catalyzed by a PDI, was more efficient and decreased the number and concentration of transiently accumulated folding species. The PDI-assisted oxidative folding of conotoxins was also influenced by the propeptide relative to the mature peptide.
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