Transdermal administration of nonsteroidal anti-inflammatory drugs using hydroxide-releasing agents as permeation enhancers
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United States of America Patent
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Jul 17, 2007
Grant Date -
Feb 5, 2004
app pub date -
Jul 30, 2003
filing date -
Dec 16, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered nonsteroidal anti-inflammatory drugs (NSAIDs). The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the NSAID through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery systems for co-administering a hydroxide-releasing agent with an NSAID are provided as well.
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