Methods and compositions for identifying receptor effectors
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United States of America Patent
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Jul 31, 2007
Grant Date -
Mar 17, 2005
app pub date -
Jan 5, 2004
filing date -
Mar 31, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors.
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