Method of detecting and evaluating angiotensinogen receptor-modulating compounds using placental cells
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United States of America Patent
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Jul 31, 2007
Grant Date -
Aug 5, 2004
app pub date -
Apr 5, 2002
filing date -
Apr 6, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Disclosed is a method of screening a substance for angiotensinogen receptor-modulatory activity. The method includes the steps of contacting placental-derived cells with labeled angiotensinogen and a candidate substance; and then determining whether the candidate substance inhibits the binding of angiotensinogen to the placental-derived cells relative to a control wherein the placental-derived cells are contacted with angiotensinogen in the absence of the candidate substance.
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