Modified adenoviral fiber and target adenoviruses
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United States of America Patent
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Aug 14, 2007
Grant Date -
Sep 18, 2003
app pub date -
Apr 1, 2003
filing date -
Apr 2, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and expression vector, and a cell line expressing said fiber, and also concerns an adenovirus, the process for producing this type of adenovirus, and an infectable host cell, as well as their therapeutic application and a corresponding pharmaceutical composition.
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