Device and method for inducing vascular injury and/or blockage in an animal model
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United States of America Patent
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Aug 21, 2007
Grant Date -
Jun 29, 2006
app pub date -
Dec 11, 2003
filing date -
Dec 11, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Ultrashort laser pulses are used to induce photodisruptive breakdown in vasculature in an animal to controllably produce hemorrhage, thrombosis or breach of the blood-brain barrier in individual, specifically-targeted blood vessels. Damage is limited to the targeted vessels such that neighboring vessels exhibit no signs of vascular damage, including vessels directly above and directly below the targeted vessel. Ultrashort laser pulses of lower energy are also used to observe and quantify the baseline and altered states of blood flow. Observation and measurement may be performed by TPLSM, OCT or other known techniques, providing a real-time, in vivo model for the dynamics and effects of vascular injury.
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