.alpha.1-6 fucosyltransferase
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United States of America Patent
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Sep 4, 2007
Grant Date -
Dec 23, 2004
app pub date -
May 13, 2004
filing date -
Jan 24, 1996
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Abstract
An isolated, porcine .alpha.1-6 fucosyltransferase having the following physico-chemical properties: (1) action: transferring fucose from guanosine diphosphate-fucose to a hydroxy group at 6-position of GluNAc closest to R of a receptor (GlcNAc.beta.1-2Man.alpha.1-6)(GlcNAc.beta.1-2Man.alpha.1-3)Man.beta.1-4G-lcNAc.beta.1-4GlucNAc-R wherein R is an asparagine residue or a peptide chain carrying said residue, whereby to form (GlcNAc.beta.1-2Man.alpha.1-6)-(GlcNAc.beta.1-2Man.alpha.1-3)Man.alpha.1--4GlcNAc.beta.1-4(Fuc.alpha.1-6)GlucNAc-R (2) optimum pH: about 7.0 (3) pH stability: retains activity after 5 hours of treatment at 4.degree. C. at a pH range of 4.0-10.0 (4) optimum temperature: about 30-37.degree. C. (5) inhibition or activation: no requirement for divalent metal for expression of activity; no inhibition of activity in the presence of 5 mM EDTA (6) molecular weight: about 60,000 by SDS-polyacrylamide gel electrophoresis is provided. An isolated polynucleotide encoding porcine .alpha.1-6 fucosyltransferase is also provided. Expression vectors comprising a polynucleotide encoding porcine .alpha.1-6 fucosyltransferase are also provided.
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