Therapeutic agents and methods of use thereof for the modulation of angiogenesis
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United States of America Patent
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Sep 11, 2007
Grant Date -
Mar 30, 2006
app pub date -
Sep 27, 2005
filing date -
Nov 1, 2000
priority date (Note) -
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Abstract
The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.
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