Membrane translocating peptide drug delivery system
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United States of America Patent
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Sep 11, 2007
Grant Date -
Jul 15, 2004
app pub date -
Jan 23, 2004
filing date -
Sep 27, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to a novel membrane translocating full-length peptide sequence, fragment, motif, derivative, analog or peptidomimetic thereof (MTLPs), to nucleotide sequences coding therefor, and to compositions comprising a MTLP-active agent complex and a MTLP-active particle complex. The MTLP or the nucleotide sequence coding therefor enhance movement of the active agent or of the active particle across a lipid membrane. More particularly, the present invention relates to a MTLP-active agent complex and a MTLP-active particle complex, wherein the MTLP enhances uptake of the active agent into a cell, into or out of an intracellular compartment and across a cell layer. Methods of making and methods of using MTLPs also are included.
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