Vascular endothelial growth factor-2
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United States of America Patent
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Sep 25, 2007
Grant Date -
Nov 20, 2003
app pub date -
Aug 3, 2001
filing date -
Aug 4, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Disclosed are human VEGF-2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF-2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides and polynucleotides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
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