Methods for synthesis of oligonucleotides

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United States of America Patent

PATENT NO 7273933
SERIAL NO

09032972

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Abstract

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Improved methods for synthesis of oligonucleotides and other phosphorus-linked oligomers are disclosed. The methods include the use of aromatic solvents, alkyl aromatic solvents, halogenated aromatic solvents, halogenated alkyl aromatic solvents, or aromatic ether solvents to achieve deprotection of protected hydroxyl groups.

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Patent Owner(s)

Patent OwnerAddress
IONIS PHARMACEUTICALS INC2855 GAZELLE COURT CARLSBAD CA 90210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Krotz, Achim H Irvine, CA 8 27
Ravikumar, Vasulinga T Carlsbad, CA 39 625

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