US Patent No: 7,278,419

Number of patents in Portfolio can not be more than 2000

Method for treating diabetes mellitus in a patient

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ALSO PUBLISHED AS: 20040182383
ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

The need for the delivery of insulin by injection can be reduced or eliminated by delivering aerosolized insulin. Repeatability of dosing is obtainable by using either regular insulin or monomeric insulin. When delivering insulin (not monomeric) by inhalation, the total inhaled volume should be about the same at each delivery to obtain repeatable results. The patient can be coached (by teaching) to inhale a given amount of air and can also be coached (by teaching) to inhale at a given flow rate. Further, the rate at which blood glucose is lowered is increased by the use of monomeric insulin. Particles of insulin and monomeric insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. A dry powder or a liquid insulin formulation is delivered to the patient from a mechanical or electronic hand-held, self-contained device.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ARADIGM CORPORATIONHAYWARD, CA118

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Farr, Stephen J Orinda, CA 40 579
Gonda, Igor San Francisco, CA 80 964
Rubsamen, Reid M Oakland, CA 95 4689

Cited Art

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6,012,450 Intrapulmonary delivery of hematopoietic drug 115 1996
5,743,250 Insulin delivery enhanced by coached breathing 116 1996
5,888,477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 29 1997
5,884,620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 46 1997
6,131,567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 43 1998
6,192,882 Formulation and devices for monitoring the efficacy of the delivery of aerosols 44 1998
6,085,753 Insulin delivery enhanced by coached breathing 37 1998
6,123,068 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 45 1998
5,873,358 Method of maintaining a diabetic patient's blood glucose level in a desired range 16 1998
5,970,973 Method of delivering insulin lispro 50 1998
6,098,615 Method of reproducibly effecting a patient's glucose level 37 1998
6,024,090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 16 1998
5,941,240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 44 1998
6,167,880 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 60 1999
6,408,854 Insulin delivery enhanced by coached breathing 23 2000
6,250,298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 38 2000
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6,431,166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 20 2001
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6,688,304 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 11 2001
6,431,167 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 6 2001
6,647,987 Insulin delivery enhanced by coached breathing 3 2002
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Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
MANNKIND CORPORATION (2)
8,377,869 Method of preventing adverse effects by GLP-1 0 2008
8,372,804 Delivery of active agents 0 2008

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