Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
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United States of America Patent
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Oct 9, 2007
Grant Date -
Aug 28, 2003
app pub date -
Oct 11, 2002
filing date -
Sep 15, 1995
priority date (Note) -
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Abstract
A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to said host cell. A method for preparing same, cells incorporating said DNA molecules and uses thereof in gene therapy are also described.
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