Nucleic acid encoding G-protein coupled receptor with modified DRY motif
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United States of America Patent
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Oct 9, 2007
Grant Date -
Mar 13, 2003
app pub date -
Jan 22, 2002
filing date -
Jan 23, 2001
priority date (Note) -
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Abstract
The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have altered DRY motifs such that the modified GPCRs are constitutively desensitized. As such, the modified GPCRs of the present invention preferably localize to endocytic vesicles or endosomes in an agonist-independent manner. The invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.
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