Method for the preparation of maytansinoid esters
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United States of America Patent
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Nov 27, 2007
Grant Date -
Jul 27, 2006
app pub date -
Jan 19, 2006
filing date -
Jan 21, 2005
priority date (Note) -
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Abstract
Improved processes for the preparation and purification of maytansinoid esters, especially thiol and disulfide-containing maytansinoids are described. In one aspect the process comprises a process of making a maytansinoid ester comprising forming an anion of maytansinol or a maytansinoid bearing a free C-3 hydroxyl moiety and reacting the anion with an activated carboxyl compound to thereby produce the maytansinoid ester.
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