Method for creating specific, high affinity nuclear receptor pharmaceuticals
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United States of America Patent
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Nov 27, 2007
Grant Date -
Jun 10, 2004
app pub date -
Dec 10, 2002
filing date -
Dec 10, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention pertains to agonists that activate nuclear receptors. These agonists include an extension that contacts a region of the nuclear receptor outside the native ligand binding pocket. Methods for producing, identifying and designing such agonists are included along with nuclear receptor agonist complexes and libraries of agonists.
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