Nano-chem-FET based biosensors
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United States of America Patent
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Dec 4, 2007
Grant Date -
Nov 15, 2007
app pub date -
Oct 9, 2003
filing date -
Oct 10, 2002
priority date (Note) -
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Abstract
Methods of detecting components of interest, e.g., nucleic acids and sugars, are provided. The methods comprise contacting one or more nanowires comprising a functional group with a sample containing the component or components of interest. In one embodiment, the functional group comprises a hairpin oligonucleotide, e.g., a hairpin that changes conformation upon binding the component of interest, e.g., a nucleic acid. The change in conformation produces a change in charge that is detected. In another embodiment, the functional group comprises an enzyme, e.g., glucose oxidase, which produces a change in pH when glucose is present in a sample.
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