Modified leukotoxin gene and protein
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Dec 4, 2007
Grant Date -
Jun 17, 2004
app pub date -
Dec 15, 2000
filing date -
Dec 17, 1999
priority date (Note) -
Expired
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Abstract
The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective against Mannheimia haemolytica in animals.
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