Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
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United States of America Patent
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Dec 11, 2007
Grant Date -
Mar 23, 2006
app pub date -
Sep 23, 2004
filing date -
Sep 23, 2004
priority date (Note) -
Expired
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Abstract
A multifunctional cross-bridged tetraaza macrocyclic compound has at least one side arm that comprises a moiety that is capable of forming a bond with another molecule, which has a targeting moiety that directs the compound to a site a marker substance. The compound is chelated to a medically active material that generates a signal for diagnostic imaging or produces a therapeutic effect at the site of the marker substance. A method for detecting, diagnosing, and/or treating a disease that produces the marker substance uses a conjugate comprising the multifunctional cross-bridged tetraaza macrocyclic compound.
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