Apparatus and method for preparative scale purification of nucleic acids
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United States of America Patent
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Jan 1, 2008
Grant Date -
Jul 27, 2006
app pub date -
Sep 12, 2003
filing date -
Sep 13, 2002
priority date (Note) -
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Abstract
Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to controllably generate bubbles that reduce the density of the cell debris and create a buoyant flocculent phase that can be readily separated from, and thus provide, a substantially clarified fluid lysate phase that is enriched in extrachromosomal DNA but substantially depleted of cellular proteins and chromosomal DNA.
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