Arrays of probes for positional sequencing by hybridization
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United States of America Patent
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Jan 15, 2008
Grant Date -
Jun 26, 2003
app pub date -
Feb 24, 1998
filing date -
Nov 6, 1992
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Abstract
This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods whereby sequence information is obtained rapidly and efficiently in discrete packages. That information can be used for the detection, identification, purification and complete or partial sequencing of a particular target nucleic acid. When coupled with a ligation step, these methods can be performed under a single set of hybridization conditions. The invention also relates to the replication of probe arrays and methods for making and replicating arrays of probes which are useful for the large scale manufacture of diagnostic aids used to screen biological samples for specific target sequences. Arrays created using PCR technology may comprise probes with 5'- and/or 3'-overhangs.
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- 15 United States
- 10 France
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- 5 Korea
- 2 Other
Patent Owner(s)
- TRUSTEES OF BOSTON UNIVERSITY
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Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Cantor, Charles R | Boston, MA | 101 | 4363 |
Prezetakiewiczr, Marek | East Boston, MA | 1 | 11 |
Sano, Takeshi | Waltham, MA | 127 | 2442 |
Smith, Cassandra L | Boston, MA | 19 | 949 |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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