Methods and compositions for identifying receptor effectors
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United States of America Patent
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Jan 15, 2008
Grant Date -
Sep 4, 2003
app pub date -
Oct 22, 2002
filing date -
Oct 7, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention makes available rapid, effective assays for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assays enable rapid screening of large numbers of polypeptides in a library to identify those polypeptides which induce or antagonize receptor bioactivity. The subject assays are particularly amenable for identifying agonists and antagonists for orphan receptors. In particular the present invention makes available novel ligand agonists of human formyl peptide receptor like-1 (FPRL-1) receptors. These novel ligand agonists are used in the assays of the invention to identify modulators of FPRL-1 receptor.
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