Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
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United States of America Patent
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Jan 22, 2008
Grant Date -
Feb 24, 2005
app pub date -
Aug 21, 2003
filing date -
Aug 21, 2003
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.
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