Compositions and methods for inhibiting expression of Huntingtin gene
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United States of America Patent
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Jan 22, 2008
Grant Date -
May 3, 2007
app pub date -
Oct 27, 2006
filing date -
Oct 28, 2005
priority date (Note) -
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Abstract
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which is less than 25 nucleotides in length and which is substantially complementary to at least a part of the HD gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the HD gene, or a mutant form thereof, using the pharmaceutical composition; and methods for inhibiting the expression of the huntingtin gene in a cell.
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