In vivo port wine stain, burn and melanin depth determination using a photoacoustic probe
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United States of America Patent
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Jan 29, 2008
Grant Date -
Feb 26, 2004
app pub date -
Feb 7, 2003
filing date -
Apr 10, 2002
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Abstract
A photoacoustic probe for port wine stain (PWS), burn and melanin depth measurements is comprised of optical fibers for laser light delivery and a piezoelectric element for acoustic detection. The probe induced and measured photoacoustic waves in acryl amide tissue phantoms and PWS skin in vivo. Acoustic waves were denoised using spline wavelet transforms, then deconvolved with the impulse response of the probe to yield initial subsurface pressure distributions in phantoms and skin. The waves were then analyzed for epidermal melanin concentration, using a photoacoustic melanin index (PAMI) related to the amount of laser energy absorbed by melanin. Propagation time of the photoacoustic wave was used to determine the depth of blood perfusion underlying necrotic, burned tissue. Thus, the photoacoustic probe can be used for determining PWS, burn and melanin depth for most patients receiving laser therapy.
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