Gene encoding protein from merozoite of Babesia caballi, recombinant protein obtained with said gene and use thereof
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United States of America Patent
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Feb 5, 2008
Grant Date -
Dec 16, 2004
app pub date -
Jun 9, 2004
filing date -
Aug 13, 1999
priority date (Note) -
Expired
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Abstract
The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In accordance with the present invention, it is possible to stably prepare the 48 kDa protein of rhoptry of Babesia caballi and the gene encoding said protein in a large amount with the recombinant DNA technique. The present invention also provides a method for diagnosing equine babesiasis which comprises either specifically detecting anti-Babesia caballi antibody present in equine blood by using the recombinant protein of present invention as an antigen or detecting the presence of Babesia caballi merozoite in equine blood by using the antibody of the present invention.
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