Device and method for monitoring leukocyte migration
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United States of America Patent
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Feb 5, 2008
Grant Date -
Jan 23, 2003
app pub date -
Sep 12, 2002
filing date -
Nov 8, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A device for monitoring leukocyte migration is provided. The device generally includes a plurality of chambers, each chamber including a channel in which leukocyte migration mediators or endothelial cells are disposed therein. The device is fabricated in the footprint of a standard microtiter plate. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. The invention further provides a method of using the device to high-throughput screen a plurality of test agents.
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