Combinatorial methods for inducing cancer cell death
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United States of America Patent
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Feb 12, 2008
Grant Date -
Sep 30, 2004
app pub date -
Feb 20, 2004
filing date -
Aug 20, 2001
priority date (Note) -
Expired
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Abstract
The present invention relates to methods and compositions for inhibiting proliferation and inducing cell death in a population of cancer cells by (i) increasing the amount of the differentiation associated protein MDA-7, and (ii) decreasing RAS activity within the population. It is based, at least in part, on the discovery that decreasing expression of a mutated, activated K-ras gene, together with introducing an expressible mda-7 gene, in pancreatic cells had a synergistic growth-inhibitory and anti-survival effect, and abolished tumorigenicity of the cells in athymic nude mice. The methods of the invention may be directed to the therapy of pancreatic cancer and other malignancies.
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