Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
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United States of America Patent
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Feb 12, 2008
Grant Date -
Nov 20, 2003
app pub date -
Dec 2, 2002
filing date -
Dec 19, 2001
priority date (Note) -
Expired
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Abstract
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
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