Composition for the elimination of autoreactive B-cells
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United States of America Patent
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Feb 19, 2008
Grant Date -
Apr 15, 2004
app pub date -
Aug 22, 2001
filing date -
Aug 22, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to a composition for the selective elimination of autoreactive B-cells comprising at least one (poly)peptide construct consisting of at least two domains wherein one of said domains comprises an autoreactive antigen or (a) fragments(s) thereof specifically recognized by the Ig receptors of said autoreactive B-cells and wherein one of said domains comprises an effector molecule capable of interacting with and/or of activating NK-cells, T-cells, macrophages, monocytes and/or granulocytes and/or capable of activating the complement system.
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