Methods and reagents for the rapid and efficient isolation of circulating cancer cells

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United States of America Patent

PATENT NO 7332288
APP PUB NO 20030129676A1
SERIAL NO

10269579

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Abstract

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A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater sensitivity than conventional PCR or immunohistochemistry by 1-2 orders of magnitude. In addition, the assay facilitates the biological characterization and staging of carcinoma cells.

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Patent Owner(s)

Patent OwnerAddress
MENARINI SILICON BIOSYSTEMS S P A40013 CASTEL MAGGIORE (BO)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liberti, Paul A Huntingdon Valley, PA 46 4237
Racila, Emilian V Dallas, TX 6 850
Rao, Galla Chandra Princeton, NJ 33 2508
Terstappen, Leon W M M Huntingdon Valley, PA 42 3041
Uhr, Jonathan W Dallas, TX 17 1393

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