3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines
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United States of America Patent
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Mar 4, 2008
Grant Date -
Feb 19, 2004
app pub date -
Nov 19, 2002
filing date -
Nov 19, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. One embodiment of the invention relates to compounds having the structure: ##STR00001## where Z is CR or N, and R.sub.1, R.sub.2 and R.sub.3 are as described in the specification.
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