US Patent No: 7,344,705

Number of patents in Portfolio can not be more than 2000

Composition comprising low density microspheres

ALSO PUBLISHED AS: 20060034772

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Abstract

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Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
LANTHEUS MEDICAL IMAGING, INC.NEW YORK, NY151

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Unger, Evan C Tucson, AZ 160 6508

Cited Art Landscape

Patent Info (Count) # Cites Year
 
LANTHEUS MEDICAL IMAGING, INC. (24)
5,088,499 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 190 1990
5,205,290 Low density microspheres and their use as contrast agents for computed tomography 120 1991
5,228,446 Gas filled liposomes and their use as ultrasonic contrast agents 94 1991
5,123,414 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 161 1991
5,230,882 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 99 1992
5,352,435 Ionophore containing liposomes for ultrasound imaging 121 1992
5,281,408 Low density microspheres and their use as contrast agents for computed tomography 153 1993
5,305,757 Gas filled liposomes and their use as ultrasonic contrast agents 96 1993
5,469,854 Methods of preparing gas-filled liposomes 188 1993
5,334,381 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same 186 1993
5,456,900 Low density microspheres and their use as contrast agents for computed tomography 69 1993
5,542,935 Therapeutic delivery systems related applications 268 1993
5,585,112 Method of preparing gas and gaseous precursor-filled microspheres 194 1993
5,830,430 Cationic lipids and the use thereof 96 1995
5,547,656 Low density microspheres and their use as contrast agents for computed tomography, and in other applications 141 1995
5,527,521 Low density microspheres and suspensions and their use as contrast agents for computed tomography and in other applications 91 1995
6,146,657 Gas-filled lipid spheres for use in diagnostic and therapeutic applications 50 1996
5,846,517 Methods for diagnostic imaging using a renal contrast agent and a vasodilator 104 1997
6,528,039 Low density microspheres and their use as contrast agents for computed tomography and in other applications 28 1997
6,548,047 Thermal preactivation of gaseous precursor filled compositions 50 1997
6,231,834 Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same 86 1997
6,551,576 Container with multi-phase composition for use in diagnostic and therapeutic applications 36 1998
6,056,938 Cationic lipids and the use thereof 48 1998
6,479,034 Method of preparing gas and gaseous precursor-filled microspheres 16 1998
 
GE HEALTHCARE AS (22)
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5,536,490 Contrast agents 107 1993
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5,558,094 Methods for using persistent gases as ultrasound contrast media 97 1995
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5,567,413 Flexible amphiphilic microbubbles for ultrasound 97 1995
5,676,928 Liposomes 86 1995
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6,331,289 Targeted diagnostic/therapeutic agents having more than one different vectors 61 1997
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CEREVAST THERAPEUTICS, INC. (8)
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IMARX THERAPEUTICS, INC. (8)
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PFC THERAPEUTICS, LLC (8)
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BRACCO SUISSE SA (7)
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5,445,813 Stable microbubble suspensions as enhancement agents for ultrasound echography 105 1993
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BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (6)
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5,849,727 Compositions and methods for altering the biodistribution of biological agents 47 1996
5,740,807 Suspended ultra-sound induced microbubble cavitation imaging 54 1996
 
BRACCO INTERNATIONAL B.V. (6)
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5,643,553 Stable microbubbles suspensions injectable into living organisms 103 1995
 
TARGESON, INC. (6)
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5,804,162 Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients 54 1995
5,733,527 Methods for harmonic imaging with ultrasound 64 1996
 
ABRAXIS BIOSCIENCE, LLC (5)
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5,508,021 Non-fluorinated polymeric shells for medical imaging 104 1994
5,505,932 Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging 131 1995
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Liposome Technology, Inc. (4)
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MASSACHUSETTS INSTITUTE OF TECHNOLOGY (4)
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PQ CORPORATION (4)
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4,549,892 Process for producing hollow, bilayered silicate microspheres 68 1983
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HemaGen/PFC (3)
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5,571,498 Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI). 30 1994
5,635,539 Stable emulsions of highly fluorinated organic compounds 24 1996
 
Minnesota Mining and Manufacturing Company (3)
5,785,950 Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of making and using them 25 1994
5,502,094 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use 70 1995
5,567,765 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods of use 83 1996
 
NYCOMED IMAGING AS (3)
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5,354,549 Iodinated esters 77 1991
5,569,449 Gaseous microparticles as ultrasound contrast agents 92 1995
 
SLF LIMITED PARTNERSHIP (3)
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4,718,433 Contrast agents for ultrasonic imaging 250 1985
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ACUSPHERE, INC. (2)
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AIR PRODUCTS AND CHEMICALS, INC. (2)
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ALLIANCE PHARMACEUTICAL CORP. (2)
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5,980,936 Multiple emulsions comprising a hydrophobic continuous phase 36 1997
 
BARNES-JEWISH HOSPITAL (2)
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CALIFORNIA INSTITUTE OF TECHNOLOGY (2)
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CAVITATION-CONTROL TECHNOLOGY, INC. (2)
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CHILDREN'S HOSPITAL RESEARCH FOUNDATION (2)
4,775,522 NMR compositions for indirectly detecting a dissolved gas in an animal 116 1985
5,536,753 Stable perfluorocarbon and oil emulsions 18 1990
 
DR. F. KOHLER CHEMIE GMBH (2)
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ELAN PHARMACEUTICALS, INC. (2)
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5,008,050 Extrusion technique for producing unilamellar vesicles 156 1989
 
EXOGEN, INC. (2)
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GORDON, DAVID, SKOKIE, ILLINOIS (2)
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KABUSHIKI KAISHA TOSHIBA (2)
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NEXSTAR PHARMACEUTICALS, INC. (2)
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NOVAVAX, INC. (2)
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SEQUUS PHARMACEUTICALS, INC. (2)
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4,534,899 Synthetic phospholipid compounds 176 1983
 
TRANSON LLC A DELAWARE CORPORATION (2)
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UNIVERSITY OF MASSACHUSETTS (2)
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YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (2)
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AECI Limited (1)
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Aktiebolaget Draco (1)
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BERSTEIN, ROBERT L. (1)
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BIOCOMPATIBLES UK LIMITED (1)
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BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC. (1)
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CALFEE HALTER & GRISWOLD, LLP (1)
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DREWES, WILLIAM (1)
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Eli Lilly and Company (1)
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FUJITSU LIMITED (1)
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HAFSTRUND NYCOMED INNOVATION, AB (1)
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HEMAGEN/PFC, 655 MONTGOMERY STREET, SUITE 1710, SAN FRANCISCO, CA. 94111, A LIMITED PARTNERSHIP OF CA. (1)
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Other [Check patent profile for assignment information] (5)
4,822,534 Method of producing microspheres 98 1987
4,996,041 Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system 106 1988
5,190,766 Method of controlling drug release by resonant sound wave 172 1991
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Patent Info (Count) # Cites Year
 
LANTHEUS MEDICAL IMAGING, INC. (4)
8,084,056 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 2 2003
8,658,205 Preparation of a lipid blend and a phospholipid suspension containing the lipid blend 0 2011
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GEORGIA-PACIFIC CHEMICALS LLC (1)
8,674,019 Composite products made with lewis acid catalyzed binder compositions that include tannins and multifunctional aldehydes 0 2013

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 Sep 18, 2015
11.5 Year Payment $7400.00 $3700.00 $1850.00 Sep 18, 2019
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00