Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
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United States of America Patent
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Mar 18, 2008
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app pub date -
Apr 18, 2003
filing date -
Jan 25, 2002
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Abstract
Ex vivo and in vivo methods of expanding a population of stem and/or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and/or progenitor cells by providing the stem and/or progenitor cells with an effective amount of at least one copper chelate, so as to maintain a free copper concentration available to said cells substantially unchanged, to thereby expand the population of said stem and/or progenitor cells, while at the same time reversibly inhibit differentiation of said stem and/or progenitor cells.
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