2,5-dioxoimidazolidin-4-yl acetamines and analogues as inhibitors of metalloproteinase mmp12

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United States of America Patent

PATENT NO 7354940
APP PUB NO 20050245586A1
SERIAL NO

10525640

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Abstract

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The invention provides compounds of formula (I) in which L, X, Y, Z.sup.1, Z.sup.2, R.sup.1, R.sup.2, R.sup.3 and G.sup.2 have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds of the invention are inhibitors of metalloproteinase MMP12 and are among other things useful for the treatment of obstructive airways diseases, such as asthma and chronic obstructive pulmonary disease (COPD).

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Patent Owner(s)

Patent OwnerAddress
ASTRAZENECA ABSE-151 85 SODERTALJE SE-151 85

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Henriksson, Krister Lund, SE 16 203
Munck, Af Rosenschold Magnus Lund, SE 8 125

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