Tetronic acid derivative
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United States of America Patent
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Apr 15, 2008
Grant Date -
Jan 20, 2005
app pub date -
May 21, 2004
filing date -
Nov 22, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present inventors intended to search for substances that can regulate the expression of a molecular chaperone, GRP78, using the expression of GRP78 as an indicator. As a result, a novel tetronic acid derivative, versipelostatin compound (also known as JL68) shown in formula (I) having the activity of suppressing GRP78 expression was isolated from the metabolite of Streptomyces versipellis strain 4083-SVS6. Versipelostatin can be obtained from the culture supernatant by culturing the above-mentioned Streptomyces versipellis strain 4083-SVS6 ##STR00001##
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