Polynucleotides encoding disorazole polyketide synthase polypeptides
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United States of America Patent
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Apr 29, 2008
Grant Date -
Feb 10, 2005
app pub date -
Dec 5, 2003
filing date -
Dec 6, 2002
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Abstract
The sequence of the disorazole polyketide synthase protein gene is disclosed. Domains of disorazole polyketide synthase and polynucleotides encoding them are provided. Methods to prepare disorazoles in pharmaceutically useful quantities are described, as are methods to prepare disorazole analogs and other polyketides using the polynucleotides encoding disorazole polyketide synthase domains or modifying enzymes.
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