Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
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United States of America Patent
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Apr 29, 2008
Grant Date -
Jul 22, 2004
app pub date -
Oct 15, 2003
filing date -
Sep 15, 1995
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Abstract
A prokaryotic recombinant host cell comprising a heterologous replication initiation protein that activates a conditional origin of replication and an extrachromosomal DNA molecule comprising a heterologous therapeutic gene and a conditional origin of replication whose functionality in the prokaryotic recombinant host cell requires a replication initiating protein which is foreign to the host cell is described. The host cell may comprise a pir gene having at least one mutation, which may occur in the pir gene copy number control region, the pir gene leucine zipper-like motif, or the pir gene DNA binding region.
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