Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
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United States of America Patent
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May 6, 2008
Grant Date -
Mar 20, 2003
app pub date -
Jun 5, 2002
filing date -
May 31, 2001
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Abstract
The present invention discloses a one-step process for the production of cytotoxic conjugates of maytansinoids and cell binding agents. Maytansinoids having a disulfide linker that bears a reactive moiety are linked to cell binding agents, such as antibodies, without prior modification of the cell binding agent. These conjugates are useful as therapeutic agents which are delivered specifically to target cells and are cytotoxic.
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