Sustained-release microparticle preparation of human growth hormone and process for producing thereof
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United States of America Patent
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May 27, 2008
Grant Date -
Nov 16, 2006
app pub date -
Jun 15, 2004
filing date -
Jun 18, 2003
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Provided is a sustained-release microparticle preparation of a human growth hormone which combines biodegradability with sustained-release performance while avoiding the use of an organic solvent as much as possible, allows the sustained-release of a human growth hormone over 3 days or more and reduction in the initial burst release, can contain a human growth hormone at 10% or more, can quantitatively adsorb and encapsulate a human growth hormone at up to 20%, and has excellent dispersion and needle penetration properties. A process for producing the sustained-release microparticle preparation of a human growth hormone is also provided. The sustained-release microparticle preparation comprises a porous apatite derivative, a human growth hormone, and a water-soluble divalent metal compound.
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