Polyketides and their synthesis and use
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United States of America Patent
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Jun 3, 2008
Grant Date -
May 18, 2006
app pub date -
Jan 10, 2006
filing date -
May 28, 1997
priority date (Note) -
Expired
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Abstract
The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded by the cluster. We have produced a mutant strain containing a rapamycin gene cluster in which the rapL gene is disabled. The strain does not naturally produce rapamycin but does so if fed with pipecolic acid. By feeding with alternative carboxylic acids we have produced variants of rapamycins. Tests have shown biological activity.
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