Oral dosage form comprising a therapeutic agent and an adverse-effect agent
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United States of America Patent
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Jun 10, 2008
Grant Date -
Mar 24, 2005
app pub date -
Sep 23, 2004
filing date -
Aug 6, 2001
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present invention provides an oral dosage form comprising a first composition and a second composition. The first composition comprises an effective amount of a therapeutic agent and the second composition comprises an effective amount of an adverse-effect agent. The adverse-effect agent is covered with a coating that is substantially insoluble in the gastrointestinal tract. In one embodiment, the adverse-effect agent is coated with an outer base-soluble layer and an inner acid-soluble layer. The therapeutic agent can be uncoated or can be coated with a coating having an outer acid-soluble layer and an inner base-soluble layer. The dosage form discourages administration of the therapeutic agent by other than oral administration.
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