Polymorphic forms of 6-11 bicyclic ketolide derivatives
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United States of America Patent
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Jun 10, 2008
Grant Date -
Sep 15, 2005
app pub date -
Feb 14, 2005
filing date -
Feb 20, 2004
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the various polymorphic forms in pure form or in combination with one another. The present invention also provides pharmaceutical compositions and formulations comprising the polymorphic and amorphous forms and methods of treating bacterial infections by administering the pharmaceutical compositions to a subject in need of such treatment.
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